The first multiple sclerosis (MS) clinical trial to focus only on people who can’t walk is to start recruiting. The ChariotMS trial, led by researchers at Queen Mary University of London, will test whether cladribine tablets (Mavenclad), already licensed for highly active relapsing MS, can slow the rate of upper limb disability progression in people with advanced MS.
To date, clinical trials for MS have not included people who are reliant on a wheelchair, and drugs have only been licensed if they improve walking ability. This means there are currently no disease modifying therapies (DMTs) available for the 35-40% of people with MS who need significant help walking.
If successful, ChariotMS could lead to the first MS drug licensed that protects upper limb function.
Tens of thousands remain without treatment
Professor Klaus Schmierer, from Queen Mary’s Blizard Institute and Barts Health NHS Trust, is leading the trial. He said: “Finding ways to maintain people’s upper limb function is essential to their quality of life, but until now walking ability has been the only official measurement of whether or not an MS treatment is effective. This has excluded people who depend on a wheelchair from taking part in trials and, as a result, from accessing effective treatment that will help maintain their hand and arm function.”
There are three main types of MS that are diagnosed—relapsing, primary progressive and secondary progressive. Thanks to research, there are over a dozen licensed DMTs for people with relapsing MS, and two for “active” progressive MS (where new lesions are visible on an MRI). But tens of thousands of people with MS remain without effective treatment.
While cladribine tablets are a highly effective treatment for people with relapsing MS, early data suggest the drug could also be effective in those with advanced MS.
From January 2021, ChariotMS will recruit 200 people with MS who can walk only a short distance with two crutches, or are unable to walk at all but retain some upper limb function. ChariotMS is also the first trial with no upper age limit.
“I worry a lot about losing the use of my right hand”
Jenny Ferguson, 63, lives in Norwich and has secondary progressive MS. She was first diagnosed with the relapsing form of MS in 1994, age 37. The former midwife became reliant on a wheelchair around seven years ago, and today her only limb function is in her right arm and hand.
Jenny said: “Only one of my four limbs actually works—my right arm. I need help with basic things like getting on and off the toilet, getting dressed and out of bed, and having my food made for me. I worry a lot about losing the use of my right hand—having a fall and fracturing it, for instance. When MS meant I had to stop working, I started painting to save my sanity, and I’m grateful I can still enjoy that. I think without painting there would be virtually no purpose to my day at all. I have sometimes felt that people like me, with advanced MS, are not seen as important. Being excluded from treatment and trials, and then being told there is nothing for you is very discouraging. Having a treatment that could preserve the use of my hand would make such a tremendous difference to my life—it would be huge.”
Improving the quality of life of people with MS
Dr. Emma Gray, Assistant Director of Research at the MS Society, says: “More than 130,000 people live with MS in the UK, and those with more advanced forms can experience difficulty with walking, relying on mobility aids like walking sticks and wheelchairs to help. But as MS progresses, many go on to experience problems with their hand and arm function too—and treatment options start to disappear. Preserving hand and arm function would unquestionably improve the quality of life of people with MS, helping them to live more independent lives. That’s why we’re so thrilled to help make this important trial a reality.”
The trial is funded by the Efficacy and Mechanism Evaluation Program, which is a partnership between the Medical Research Council and National Institute for Health Research, and will receive additional funding from the MS Society, the National MS Society U.S., Barts Charity, and Merck Serono.
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