Blood group affected, according to the study, the Severity of the disease process

An employee of the Robert Koch Institute (RKI) labeled a blood test for an antibody test

During a Covid-19-disease failure in some people, to Breath, to death, to feel others barely the symptoms.

The reasons for the very different histories are still largely unclear, but an important factor could be the blood group, as an international team of researchers in the “New England Journal of Medicine” reported. Therefore, people in Germany, most common blood group A have. a nearly 50 percent higher risk for a severe course of Infection than those with other blood groups People with blood group 0 according to the study, approximately a 50 percent lower risk for a serious Covid-19-disease.

New Corona Study

People with certain blood groups might be at Covid-19 particularly at risk

The Team of molecular biologists, Andre Franke, University hospital of Kiel, had published his results earlier as a Preprint, i.e. without peer review by independent scientists. The study is published in a very prestigious scientific journal.

The researchers had blood samples from 1610 to Covid-19 patients from seven hospitals intensively in Italy and Spain is analysed. All patients were treated with oxygen, were connected to a respirator. In addition, the researchers examined blood samples from 2205 randomly selected men and women from the same countries as the control group. They analyzed the genetic material of the people.

Absolute risks are not calculated in the study

“Using this large amount of data, we have identified interesting regions in the genome that increase the risk for a severe course of Covid-19, respectively, to reduce” is first cited author, David ellinghaus from Kiel, in a communication of the University hospital.

The researchers identified a gene variant that was associated with a severe Covid-19-course, on chromosome 9. The AB0 is a Gene, of which the blood group of a person depends. Patients with blood group A had a particularly high risk for respiratory problems in the course of a Covid-19 infection, such as in Germany, are also common blood group 0 were better. In Germany, 43 per cent of the human blood group A, 11 per cent of blood group B, 5% blood group AB and 41 per cent of blood group 0 have.

With what are the absolute risks of the various blood groups are associated to a severe Covid-19-disease, on average, not determined in the study. The results fit to the results of two other Preprint-studies from China and the United States, which had examined the blood of Covid-19-patients. “These two groups have studied human serologically, we came from the genetic side,” explains Franke. “This brings additional evidence.”


Blood group A is equal to high risk? What’s up with the Corona-blood groups-a study on

The authors do not know why the blood group can affect the Severity of a Covid-19 infection. However, the Locus for the blood group was associated substances with specific inflammatory messengers. Other studies have shown that the Virus leads some Patients to an Overreaction of the immune system with strong inflammatory reactions in the body.

“The results were very exciting and surprising”

In addition to chromosome 9-localized the molecular biologists an even higher effect size for a genetic variant on chromosome 3. Which genes are responsible for this, don’t know, the scientists. Carriers of this variant had the disease compared to other people, a doubled risk for a severe Covid-19 -. Strikingly, many of these difficult Patients had blood group A.

“The results were very exciting and surprising,” says Franke. The Region on chromosome 3 was previously not yet been associated with Covid-19 in connection. “With the chromosome 3 and the AB0 blood group Locus, we describe the real causes for a severe course of Covid-19,” he says. “Our results therefore provide an excellent basis for the development of drugs that can start at the found candidate genes.” In addition, the results could improve the risk assessment for a Covid-19-history.

That there may be correlations between the blood group of a people and in certain diseases is not new. As has already been observed that people with blood group 0 less cardiovascular to develop diseases than other blood groups-types, while those with blood group AB rare high blood pressure. The reasons for these correlations have not been clarified.

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